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Abstract #0905

High resolution multifrequency MR elastography of hepatic tumors for measurement of stiffness and mechanical heterogeneity

Mehrgan Shahryari1, Jing Guo1, Florian Dittmann1, Heiko Tzschätzsch1, Sebastian Hirsch1, Eric Barnhill1, Georg Böning1, Uli Fehrenbach1, Timm Denecke1, Jürgen Braun1, and Ingolf Sack1

1Charité - Universitätsmedizin Berlin, Berlin, Germany

High-resolution MRE of the liver based on multifrequency wave excitation and tomoelastography reconstruction is proposed for the mechanical characterization of hepatic tumors including stiffness and heterogeneity of the mechanical properties. We investigated 62 tumors in 43 patients and observed that high-grade tumors are stiffer than surrounding parenchyma, while low-grade hepatic adenoma had no altered stiffness. The intra-tumor heterogeneity of stiffness values was higher than in non-tumorous liver tissue. The proposed multifrequency MRE protocol could easily be integrated into the standard radiological workflow of our institution, thereby adding valuable information on tumor aggressiveness to standard clinical imaging markers.

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