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Abstract #0909

Dynamic Gadoxetate Enhanced MRI measurement of segmental liver function – A novel imaging biomarker for predicting Post-Hepatectomy Liver Failure

David Alexander Longbotham1, Daniel Wilson2, Ashley Guthrie3, Ernest Hidalgo1, Raj Prasad1, and Steven Sourbron4

1Department of HPB and Transplantation Surgery, St James's University Hospital, Leeds, United Kingdom, 2Department of Medical Physics, St James's University Hospital, Leeds, United Kingdom, 3Department of Radiology, St James's University Hospital, Leeds, United Kingdom, 4Division of Biomedical Imaging, University of Leeds, Leeds, United Kingdom

Current risk assessment for post-hepatectomy liver failure (PHLF) is based on the volume of the future liver remnant (FLR). This is inaccurate when liver function is inhomogeneously distributed. We investigated whether the function of the FLR measured with DCE-MRI improves outcome predictions in 28 patients who had curative resection for colorectal liver metastases. We found the difference in preoperative estimates of FLR function and volume predicted PHLF with a sensitivity of 83% and specificity of 91%, indicating that: (1) inhomogeneous distribution of function is a major risk factor for PHLF; (2) DCE-MRI can improve patient outcome by correcting for the bias caused by volumetry.

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