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Abstract #0922

Quantification of Increased Myocardial Stiffness in Patients with Hypertrophic Cardiomyopathy Using 3D High Frequency Cardiac Magnetic Resonance Elastography

Shivaram Poigai Arunachalam1, Arvin Arani1, Ian Chang2, Yi Sui1, Phillip Rossman1, Kevin Glaser1, Joshua Trzasko1, Kiaran McGee1, Armando Manduca3, Richard Ehman1, Richard Ehman1, and Philip Araoz1

1Radiology, Mayo Clinic, ROCHESTER, MN, United States, 2Cardiovascular Diseases, Mayo Clinic, ROCHESTER, MN, United States, 3Biomedical Engineering and Physiology, Mayo Clinic, ROCHESTER, MN, United States

Abnormal thickening of myocardium in patients with hypertrophic cardiomyopathy impairs the pump function, and in particular affects diastolic filling with a known increase in myocardial stiffness. The purpose of this work was to determine if 3D high frequency cardiac MR elastography (MRE) can quantitatively differentiate increased myocardial stiffness in HCM patients compared to healthy volunteers. 36 patients with clinical diagnosis for hypertrophic cardiomyopathy (HCM) and 47 healthy volunteers were studied. The myocardial stiffness of HCM patients (mean: 12.01 kPa) was found to be significantly stiffer (p < 0.01) than healthy controls (mean: 7.79 kPa).

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