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Abstract #0921

Longitudinal MRS, MRI and DTI of the spinal cord in Friedreich’s Ataxia

Pierre-Gilles Henry1, James M Joers1, Dinesh K Deelchand1, Diane Hutter1, Khalaf O Bushara1, Gülin Öz1, and Christophe Lenglet1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

We report the first longitudinal MRS, structural MRI, and diffusion MRI data in the cervical spinal cord of subjects with Friedreich’s ataxia. We were able to detect significant changes in spinal cord area (-18%), tNAA/mIns ratio (-17%), fractional anisotropy (-11%) and mean diffusivity (+26%) in a group of 10 patients over 24 months. Our data suggest that MR of the spinal cord could be useful to assess the impact of potential treatments on neurodegeneration in upcoming clinical trials in FRDA.

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