We report the first longitudinal MRS, structural MRI, and diffusion MRI data in the cervical spinal cord of subjects with Friedreich’s ataxia. We were able to detect significant changes in spinal cord area (-18%), tNAA/mIns ratio (-17%), fractional anisotropy (-11%) and mean diffusivity (+26%) in a group of 10 patients over 24 months. Our data suggest that MR of the spinal cord could be useful to assess the impact of potential treatments on neurodegeneration in upcoming clinical trials in FRDA.
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