Cardiac magnetic resonance (CMR) can detect inflammatory myocardial alterations in patients with acute myocarditis. The addition of myocardial strain analysis might further broaden the diagnostic targets of CMR. We investigated myocarditis patients using multiparametric CMR including a feature-tracking analysis of myocardial strain parameters. We could demonstrate that myocardial strain measurements can reliable discriminate between diseased and healthy patients. Furthermore, strain measurements are associated with the extent of myocardial edema/inflammation. These findings indicate that CMR feature-tracking strain analysis adds important diagnostic information, and might serve as a new tool for the assessment of myocardial dysfunction in patients with acute myocarditis.