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Abstract #0929

Characterisation of in-vivo and ex-vivo cardiac Diffusion Tensor Imaging scalar measures of cardiac microstructure in healthy swine

Sonia Nielles-Vallespin1,2, Pedro F Ferreira2, Andrew D Scott2, Ranil de Silva2, Philip Kilner2, Daniel B Ennis3, Dudley J Pennell2, David N Firmin2, and Andrew E Arai1

1NHLBI, NIH, Bethesda, MD, United States, 2Royal Brompton Hospital, Imperial College of London, London, United Kingdom, 3Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States

In-vivo cDTI was performed at several cardiac phases in healthy swine (N=16), followed by ex-vivo cDTI in two contractile states. The three eigenvalues (L1, L2, L3), MD, FA and Mode were compared. All trends between in-vivo diastole and systole matched those between ex-vivo relaxed and contracted states, except for MD, which decreased ~10% in-vivo from diastole to systole, with no significant differences ex-vivo between relaxed and contracted states. These results provide a useful baseline for future preclinical studies with cardiac disease models, and might contribute towards formulating a strain correction model that accounts for the microstructural constraints and deformations of the myocardium.

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