Abstract #0930

Strain analysis methods from CMR more sensitive than echocardiographic methods to small differences in cardiotoxicity remodeling between risk groups of cancer survivors.

Delphine Perie¹, Hadi Begdouri¹, Mohamed Aissiou¹, Farida Cheriet¹, Tarik Hafyane², Matthias Friedrich³, Caroline Laverdière⁴, Maja Krajinovic⁵, Daniel Sinnett⁵, Gregor Andelfinger⁶, and Daniel Curnier⁷

¹Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³Health Center, McGill University, Montreal, QC, Canada, ⁴Pediatric Oncology, CHU Sainte-Justine, Montreal, QC, Canada, ⁵Research Center, CHU Sainte-Justine, Montreal, QC, Canada, ⁶Pediatric Cardiology, CHU Sainte-Justine, Montreal, QC, Canada, ⁷Kinesiology, Université de Montréal, Montreal, QC, Canada

The use of cardiac strain mapping may provide useful knowledge that may help in detecting doxorubicin-induced cardiotoxicity at a functional scale. Although the feasibility of CMR has been established, there are no standard acquisition protocols or processing pipelines to assess cardiac strain maps. Compared to echocardiography, strain analysis methods from CMR are more sensitive to small differences in cardiotoxicity between risk groups in cancer survivors. While strain mapping from echocardiography remains adequate to detect large differences between healthy volunteers and patients with diseases, our study highlighted the necessity to combine different strain mapping methods to fully describe small cardiac damages

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