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Abstract #0930

Strain analysis methods from CMR more sensitive than echocardiographic methods to small differences in cardiotoxicity remodeling between risk groups of cancer survivors.

Delphine Perie1, Hadi Begdouri1, Mohamed Aissiou1, Farida Cheriet1, Tarik Hafyane2, Matthias Friedrich3, Caroline Laverdière4, Maja Krajinovic5, Daniel Sinnett5, Gregor Andelfinger6, and Daniel Curnier7

1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Research Center, Montreal Heart Institute, Montreal, QC, Canada, 3Health Center, McGill University, Montreal, QC, Canada, 4Pediatric Oncology, CHU Sainte-Justine, Montreal, QC, Canada, 5Research Center, CHU Sainte-Justine, Montreal, QC, Canada, 6Pediatric Cardiology, CHU Sainte-Justine, Montreal, QC, Canada, 7Kinesiology, Université de Montréal, Montreal, QC, Canada

The use of cardiac strain mapping may provide useful knowledge that may help in detecting doxorubicin-induced cardiotoxicity at a functional scale. Although the feasibility of CMR has been established, there are no standard acquisition protocols or processing pipelines to assess cardiac strain maps. Compared to echocardiography, strain analysis methods from CMR are more sensitive to small differences in cardiotoxicity between risk groups in cancer survivors. While strain mapping from echocardiography remains adequate to detect large differences between healthy volunteers and patients with diseases, our study highlighted the necessity to combine different strain mapping methods to fully describe small cardiac damages

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