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Abstract #0947

Quantitative non-Gaussian diffusion and IVIM MRI: Correlation between synthetic parameters and breast cancer biomarkers

Mami Iima1,2, Masako Kataoka1, Shotaro Kanao1, Natsuko Onishi1, Makiko Kawai1, Akane Ohashi1, Rena Sakaguchi1, Ayami Ohno Kishimoto1, Masakazu Toi3, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, 3Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

The association of IVIM/non-Gaussian diffusion MRI parameters with biological feature or subtypes in breast cancer was evaluated. For 144 malignant lesions, IVIM (fIVIM,D*) and non-Gaussian diffusion (ADCo,K) parameters were estimated from DWI series with 16 b values (0-2500sec/mm2), as well as syntheticADC (sADC) (b=200,1500sec/mm2) and ADC (b=0,800sec/mm2). sADC and K values were significantly different between ER,PgR,andHer2 status (p<0.05,0.01,0.05 for sADC and p<0.05,0.05,0.05 for K). There was a significant difference of ADC values between PgRandHer2 status (p<0.05,0.01). No significant difference of IVIM was found. ADCo, sADC, and ADC showed the statistical significance in differentiating subtypes of breast cancer (p<0.05,<0.01,<0.01).

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