Abstract #0948

B1 Mapping for Breast Sodium MRI at 7T- A Comparison between Double Angle and Phase-sensitive Method

Olgica Zaric^1,2, Lenka Minarikova¹, Sefan Zbyn^1,3, Armin Nagel^4,5, Lena Gast⁴, and Siegfrid Trattnig¹

¹Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MRI, Christian Doppler Forschungsgesellschaft, Vienna, Austria, ³Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ⁴Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁵Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany

Absolute values of sodium content in tumors is one of the most important biomarkers for cancer diagnostics and therapy monitoring. An accurate quantitative values are influenced by B1 inhomogeneity that must be evaluated and corrected. In this work, we compared two mapping methods DAM and PS. On the basis of our results, we found that DAM gives overestimated flip angle values (approximately 30% higher than PS). Also, after correction is applied, DAM shows higher signal drop in comparison with PS. Accompanied with longer measurement time necessary for DAM, this findings give advantages to PS in clinical studies and routine implementation.

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