Abstract #0949

Reproducibility of ADC measures by Breast DWI: Results of the ACRIN 6698 Trial

David C Newitt¹, Zheng Zhang², Jessica Gibbs¹, Savannah C Partridge³, Thomas L Chenevert⁴, Patrick J Bolan⁵, Mark Rosen⁶, Helga Marques², and Nola Hylton¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, ²Biostatistics, Brown University, Providence, RI, United States, ³Radiology, University of Washington, Seattle, WA, United States, ⁴Radiology, University of Michigan Health System, Ann Arbor, MI, United States, ⁵Radiology, University of Minnesota, Minneapolis, MN, United States, ⁶University of Pennsylvania, Philadelphia, PA, United States

The multi-institutional ACRIN 6698 trial investigates quantitative diffusion weighted imaging (DWI) for assessment of breast cancer response to treatment. A secondary aim is to perform a test/retest study to evaluate reproducibility of ADC measures. In a subset of 91 subjects, DWI was acquired twice in the same exam, before and after patient repositioning. Tumor ADC was measured separately for each acquisition. 80% of cases were found analyzable by a standardized quality-control procedure. Reproducibility of ADC was excellent, with intraclass correlation coefficient of 0.97 (95%CI 0.95, 0.98) and agreement index of 0.83 (95%CI 0.76,0.87). Results were similar for subgroups by field strength or study visit.

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