Tumors are typically heterogeneous, and may contain different grades of tumor cells, different types of tumor cells, edema and/or abnormal vascular structures. A noninvasive, non-radioactive technique to provide multiple parametric and quantitative images for better profiling the heterogeneity of tumors is highly needed. We demonstrated that diffusion basis spectrum imaging with extended isotropic spectrum (DBSI-EIS) is capable to identify structural heterogeneity in brain tumor lesions, including various grades of tumor cells and perfusion, which make it a new and unique technique to clinically evaluate tumors for comprehensive diagnosis and accurate treatment evaluation.
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