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Abstract #0974

Monitoring Glioblastoma Progression in Mouse Brain with Magnetic Resonance Elastography

Navid Nazari1, Michal Nowicki2, Katharina Shregel2,3, Sean Lawler2,4, Ralph Sinkus5, Paul Barbone1, and Samuel Patz2,4

1Boston University, Boston, MA, United States, 2Brigham and Women's Hospital, Boston, MA, United States, 3University Medicine Goettingen, Goettingen, Germany, 4Harvard Medical School, Boston, MA, United States, 5King's College, London, United Kingdom

The longitudinal progression of glioblastoma was monitored in a cohort of mice with MRE and conventional RARE MRI. Increasing tumor size was easily seen with both modalities. In most cases, MRE maps showed a tumor margin that was sharper than RARE. Results were registered with histology, and variation of the shear modulus was compared with histology features. Both MRE and RARE demonstrated tumor regions with varying levels of heterogeneity, and in one animal, both homogeneous and heterogeneous parts were found to be growing separately as sub-populations of the same glioblastoma cell line within the brain.

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