Optic pathway glioma (OPG) is a childhood tumour of the visual pathway. Some OPG patients remain stable, whereas others experience rapid visual decline; however, conventional MRI cannot stratify these patients. We used multi-shell DTI to measure tumour invasion of the optic pathway in 23 OPG patients, in conjunction with visual assessment. A strong correlation was found between fractional anisotropy in the optic nerves and optic radiations, and visual acuity (p=0.00092 and p=0.008 respectively). Our study demonstrates that multi-shell diffusion-MRI offers increased sensitivity over conventional MRI in detecting white matter integrity and function in the visual pathway of OPG patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords