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Abstract #0985

Pipeline for longitudinal assessment of patient-derived mouse xenografts using 3D magnetization transfer-weighted MRI

Kimberly L. Desmond1, David Bakhshinyan2, Maleeha Qazi2, Parvez Vora2, Chirayu Chokshi2, Sheila K. Singh2, and Nicholas A. Bock1

1Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada, 2McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

A pipeline was developed, driven by 3D magnetization transfer-weighted images acquired without contrast agent, to automatically assess mouse models of patient-derived tumours against an atlas of control NOD-SCID mice, for the purposes of longitudinal, high-throughput screening of mice for response to cancer therapy and recurrence.

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