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Abstract #0986

Tumor Interstitial Fluid Pressure and Hydraulic Conductivity Estimates by DCE-MRI in a Rat Model of Cerebral Tumor

Rasha Elmghirbi1,2, Nagaraja N. Tavarekere3, Stephen L. Brown4, Swayamprava Panda1, Kelly A. Keenan3, Glauber Cabral1, Hassan Bagher-Ebadian2,4, and James R. Ewing1,2

1Neurology, Henry Ford Hospital, Detroit, MI, United States, 2Physics, Oakland University, Rochester Hills, MI, United States, 3Neurosurgery, Henry Ford Hospital, Detroit, MI, United States, 4Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States

An elevated tumor interstitial fluid pressure (TIFP) is a critical element for assessing therapeutic response. This study demonstrates the use of DCE-MRI to estimate TIFP, and validates that estimate by an invasive method in a rat glioblastoma model, with and without treatment interventions. Significant positive correlations between MRI-derived TIFP estimates and invasive measures of TIFP were found in all groups (e.g., for untreated group, R2=0.76, p<0.0001). These findings validate an MRI-estimated TIFP as a noninvasive measure of TIFP in embedded cerebral tumors, and suggest that it may be a useful tool in assessing tumor response to therapy.

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