An elevated tumor interstitial fluid pressure (TIFP) is a critical element for assessing therapeutic response. This study demonstrates the use of DCE-MRI to estimate TIFP, and validates that estimate by an invasive method in a rat glioblastoma model, with and without treatment interventions. Significant positive correlations between MRI-derived TIFP estimates and invasive measures of TIFP were found in all groups (e.g., for untreated group, R2=0.76, p<0.0001). These findings validate an MRI-estimated TIFP as a noninvasive measure of TIFP in embedded cerebral tumors, and suggest that it may be a useful tool in assessing tumor response to therapy.
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