Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brain tumour with very poor outcome. The local brain microenvironment appears to play an important role in the tumourigenesis of DIPG, and is currently underinvestigated. Infratentorial and hemispheric tumour growth patterns of orthotopic DIPG xenografts were assessed longitudinally by anatomical MRI, and confirmed by immunohistochemical analysis. ADC, T1 and T2 were higher in infratentorial tumours than hemispheric tumours, corresponding to a higher degree of tumour-associated oedema observed histologically.
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