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Abstract #0987

A preclinical MRI study investigating the impact of the local microenvironment on the progression of diffuse intrinsic pontine glioma in patient-derived xenografts

Mariama Fofana1, Jessica KR Boult1, Maria Vinci1, Valeria Molinari1, Kathryn Taylor1, Sergey Popov1, Alan Mackay1, Chris Jones1, and Simon P Robinson1

1The Institute of Cancer Research, London, United Kingdom

Diffuse intrinsic pontine glioma (DIPG) is a devastating childhood brain tumour with very poor outcome. The local brain microenvironment appears to play an important role in the tumourigenesis of DIPG, and is currently underinvestigated. Infratentorial and hemispheric tumour growth patterns of orthotopic DIPG xenografts were assessed longitudinally by anatomical MRI, and confirmed by immunohistochemical analysis. ADC, T1 and T2 were higher in infratentorial tumours than hemispheric tumours, corresponding to a higher degree of tumour-associated oedema observed histologically.

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