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Abstract #0997

CEST-weighted MRI at 21.1 T: application to glioma and ischemic rat model

Tangi Roussel1,2, Jens T. Rosenberg3, Samuel C. Grant 3,4, and Lucio Frydman2

1NeuroSpin, Commisariat à l'Energie Atomique et aux Energies Alternatives, Gif-sur-Yvette, France, 2Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 3National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 4Department of Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States

This study explores and demonstrates the opportunities opened by ultrahigh fields for in vivo CEST-weighted imaging. CEST-weighted fast spin-echo imaging was performed on two neurological models: hypoxic ischemic and glioblastoma. A remarkably strong CEST contrast (≈15%) was observed for the tumors at 3.32 ppm originating mainly from an APT increase and a strong decrease in NOE and MT. Ischemic lesions were still more robustly detected with standard T2-weighted images than with CEST. Potential explanations and dependence with high magnetic field are discussed.

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