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Abstract #1000

The T1-Dispersion Curve as a Biomarker of Colorectal Cancer

Vasileios Zampetoulas1, Lionel M. Broche1, Graeme I. Murray2, and David J. Lurie1

1Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, AB25 2ZD, Scotland, United Kingdom, 2Department of Pathology, University of Aberdeen, AB25 2ZD, Scotland, United Kingdom

A graph of T1 versus applied magnetic field, obtained via Fast Field-Cycling (FFC) NMR relaxometry, can be used as a diagnostic tool thanks to the information it provides about molecular dynamics. In this work, FFC NMR relaxometry, extended to magnetic fields below 17 μT, was used to investigate new biomarkers of colorectal cancer. The acquired results indicated that there were significant differences in the molecular motions with correlation times 0.1-10 ms and 0.5–1.4 μs between the healthy and cancer tissues examined, showing great potential for diagnosis, staging and monitoring response to treatment.

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