Prostate cancer is the most common malignancy in men. T2-weighted magnetic resonance imaging (MRI) has been shown to provide detailed information about anatomical structures but suffers from low specificity of morphological abnormalities. To enhance identification of malignant lesions, we set up a multi-parametric and multi-nuclear clinical protocol, in which sodium (23Na-) MRI and diffusion weighted imaging with standard and high b-values are added to the morphological T2-weighted sequences. Using a double resonant 23Na/1H abdominal coil allows acquiring sodium images directly after high resolution clinical proton sequences. Coil changes become unnecessary, which improves clinical feasibility.