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Abstract #1027

Quantitative four-dimensional motility tracking of individual immune cells in living mouse brain

Yuki Mori1,2, Daniela Martinez de la Mora1,2, Atsuki Tashita3, Syoji Kobashi3, Ikuhiro Kida2, Yutaka Hata4, and Yoshichika Yoshioka1,2

1Biofunctional Imaging, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, 2Center for Information and Neural Networks, National Institute of Information and Communications Technology and Osaka University, 3Graduate School of Engineering, University of Hyogo, 4Graduate School of Simulation Studies, University of Hyogo

Improved imaging techniques are being used to broaden the scope and better understanding of the complex cell behaviours in the body. Nonetheless, the migratory behavior of immune cells after CNS injury is still poorly understood. In this study, we employed four-dimensional (4D) MRI to monitor the dynamic migration of infiltrating monocytes/macrophages in the living mouse brain. Our results demonstrate the possibility of non-invasive long-term monitoring of individual live cells. Moreover, this innovative technique furthers our understanding of the cellular mechanisms occurring in the normal and injured brain tissues.

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