Abstract #1027

Quantitative four-dimensional motility tracking of individual immune cells in living mouse brain

Yuki Mori^1,2, Daniela Martinez de la Mora^1,2, Atsuki Tashita³, Syoji Kobashi³, Ikuhiro Kida², Yutaka Hata⁴, and Yoshichika Yoshioka^1,2

¹Biofunctional Imaging, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, ²Center for Information and Neural Networks, National Institute of Information and Communications Technology and Osaka University, ³Graduate School of Engineering, University of Hyogo, ⁴Graduate School of Simulation Studies, University of Hyogo

Improved imaging techniques are being used to broaden the scope and better understanding of the complex cell behaviours in the body. Nonetheless, the migratory behavior of immune cells after CNS injury is still poorly understood. In this study, we employed four-dimensional (4D) MRI to monitor the dynamic migration of infiltrating monocytes/macrophages in the living mouse brain. Our results demonstrate the possibility of non-invasive long-term monitoring of individual live cells. Moreover, this innovative technique furthers our understanding of the cellular mechanisms occurring in the normal and injured brain tissues.

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