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Abstract #1031

Maternal and fetal glucose uptake followed by chemical exchange saturation transfer imaging (glucoCEST) on pregnant mice at 21.1T

Stefan Markovic1, Jens Rosenberg2, Shannon Helsper2, Tangi Roussel3, Michal Neeman4, Samuel Grant2,5, and Lucio Frydman1

1Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 3NeuroSpin Centre CEA Saclay, Gif-sur-Yvette, France, 4Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 5Chemical & Biomedical Engineering Department, FAMU-FSU College of Engineering, Tallahassee, FL

GlucoCEST generates a contrast that is sensitive to glucose uptake and metabolism. While previously shown with tumor models, a distinct glucose metabolism is also characteristic of pregnancy. This study explores the potential of glucoCEST under this condition. Glucose was administered to pregnant mice by gavage in a manner akin to that used in human pregnancy-induced diabetes tests, and subsequently monitored in-vivo by glucoCEST at 21.1T. Distinct differences were apparent upon instituting glucose, with organ-specific glucoCEST contrast exceeding 50-70%. Notable imaging differences were noted between dame and fetuses upon glucose gavage, as well as between pregnant and non-pregnant animals.

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