Fibrogenesis is a feature of idiopathic pulmonary fibrosis (IPF) that leads to the increased deposition and cross-linking of collagen. There remains a demand for non-invasive imaging of fibrogenesis in patients with suspected IPF to deliver earlier diagnoses and monitor treatment response. One universal feature of fibrogenesis is the oxidation of lysines on collagen to form allysine, which is a fundamental component for the cross-linking of collagen. We developed GdOA, a Gd-based MR probe that targets allysine as a marker for active fibrogenesis. We demonstrate that GdOA MR signal enhancement correlates with extent of disease and is sensitive to therapeutic response.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords