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Abstract #1032

Molecular MR imaging of pulmonary fibrogenesis using the novel probe GdOA

Philip Alan Waghorn1, Chloe Jones1, Clemens Probst2, Diego Ferreira1, Nicholas Rotile1, Howard Chen1, Andrew Tager2, and Peter Caravan1

1A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, United States

Fibrogenesis is a feature of idiopathic pulmonary fibrosis (IPF) that leads to the increased deposition and cross-linking of collagen. There remains a demand for non-invasive imaging of fibrogenesis in patients with suspected IPF to deliver earlier diagnoses and monitor treatment response. One universal feature of fibrogenesis is the oxidation of lysines on collagen to form allysine, which is a fundamental component for the cross-linking of collagen. We developed GdOA, a Gd-based MR probe that targets allysine as a marker for active fibrogenesis. We demonstrate that GdOA MR signal enhancement correlates with extent of disease and is sensitive to therapeutic response.

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