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Abstract #1034

MR molecular imaging of extradomain-B fibronectin for characterizing prostate cancer aggressiveness

Zheng Han1, Sarah Roelle1, Yuchi Liu1, Xin Yu1, and Zheng-Rong Lu1

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Accurate risk stratification is critical to the clinical management of prostate cancer. The objective of our study is to investigate the effectiveness of MR molecular imaging of EDB-FN for non-invasive localization and characterization of prostate cancer aggressiveness. An EDB-FN targeting Gd-based contrast, ZD2-Gd(HP-DO3A), was designed and synthesized. Molecular MRI of EDB-FN with ZD2-Gd(HP-DO3A) can specifically improve contrast enhancement in high-risk prostate tumors, not low-risk tumors, enabling accurate characterization of prostate cancer aggressiveness. Molecular MRI with the contrast agent has great promise for detection of high-risk prostate cancer, and non-invasive differential diagnosis and risk stratification of human prostate cancer.

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