L-type voltage-dependent Ca2+ channels of type Cav1.2, but not Cav1.3, are essential for Mn2+ accumulation in MEMRI. Cav1.2 conditional knock-out animals were exploited to show that a bias exists towards Mn2+ accumulation in axon terminals and highly dense output structures. Our results have strong implications for the analysis of activity dependent Mn2+ accumulation.
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