Meeting Banner
Abstract #1035

The Role of the L-type calcium channel Cav1.2 in MEMRI

Benedikt Bedenk1, Suellen Almeida-Correa1, Carsten T Wotjak1, and Michael Czisch1

1Max Planck Institute of Psychiatry, Munich, Germany

L-type voltage-dependent Ca2+ channels of type Cav1.2, but not Cav1.3, are essential for Mn2+ accumulation in MEMRI. Cav1.2 conditional knock-out animals were exploited to show that a bias exists towards Mn2+ accumulation in axon terminals and highly dense output structures. Our results have strong implications for the analysis of activity dependent Mn2+ accumulation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here