Abstract #1039

Wave-CAIPI ViSTa: Accelerated mapping for direct visualization of myelin water

Zhe Wu¹, Berkin Bilgic^2,3, Hongjian He¹, Yi Sun⁴, Kawin Setsompop^2,3, and Jianhui Zhong¹

¹Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, People's Republic of China, ²Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴MR Collaboration NE Asia, Siemens Healthcare, Shanghai, People's Republic of China

Direct Visualization of Short Transverse relaxation time component (ViSTa) is a new myelin water imaging method, which directly extracts myelin water signal through double inversion RF pulses (DIR) to preserve signal from short T₁ components. This method is robust and sensitive to demyelinated lesions, but suffers from extremely long scan time. Herein, we propose accelerated ViSTa acquisition through Simultaneous Multi-Slice (SMS) wave-CAIPI while keeping the high fidelity of ViSTa and MWF maps. As the average/maximum g-factor noise amplification is only 3/10% at MultiBand-4, further acceleration is likely to shorten whole brain MWF acquisition to within 5 minutes.

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