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Abstract #1039

Wave-CAIPI ViSTa: Accelerated mapping for direct visualization of myelin water

Zhe Wu1, Berkin Bilgic2,3, Hongjian He1, Yi Sun4, Kawin Setsompop2,3, and Jianhui Zhong1

1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, People's Republic of China, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, People's Republic of China

Direct Visualization of Short Transverse relaxation time component (ViSTa) is a new myelin water imaging method, which directly extracts myelin water signal through double inversion RF pulses (DIR) to preserve signal from short T1 components. This method is robust and sensitive to demyelinated lesions, but suffers from extremely long scan time. Herein, we propose accelerated ViSTa acquisition through Simultaneous Multi-Slice (SMS) wave-CAIPI while keeping the high fidelity of ViSTa and MWF maps. As the average/maximum g-factor noise amplification is only 3/10% at MultiBand-4, further acceleration is likely to shorten whole brain MWF acquisition to within 5 minutes.

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