Novel 3D Yarn-Ball k-space acquisition is applied for the first time in vivo with application to T1-weighted human brain imaging and a goal of 0.9x0.9x0.9 mm3 voxels in ~2 minutes at 3T. This efficient, large-looping trajectory allows much more of k-space to be sampled following each excitation than the 1 line of 3D-Gradient-Echo (3D-GRE), facilitating longer repetition times (TR), greater acquisition duty cycle, and full sampling. We demonstrate that as a result images created with Yarn-Ball yield better resolution phantom element distinction, and considerably higher SNR (2x on average) in vivo than the three different 3D-GRE methods tested.
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