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Abstract #1057

A new pulse sequence for single-voxel 1H MRS measurement of cerebral Nicotinamide adenine dinucleotide (NAD+) in humans at 7T using 32-channel volume coil

Puneet Bagga1, Hari Hariharan1, Kevin D'Aquilla1, Ravi Prakash Reddy Nanga1, Mohammad Haris2, and Ravinder Reddy1

1Department of Rediology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar

Nicotinamide adenine dinucleuotide (NAD+) is a ubiquitous molecule present in all cells and tissues of the body with an important role in the redox reactions and metabolism. Small changes in NAD+ levels may lead to oxidative stress and may be a cause for various disorders. Currently, NAD+ can be detected in vivo only by 31P NMR spectroscopy. Recently, NAD+ measurement with 1H MRS in the human brain with a surface coil was demonstrated. In the present study, we show a novel MR pulse sequence for the in vivo, single voxel localized detection of NAD+ from the human brain at 7T.

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