Abstract #1058

Detection of MM using metabolite-nulled MEGA-LASER at 3T – A possible effect on GABA+ signal

Michal Považan^1,2, Petra Hnilicová³, Gilbert Hangel¹, Bernhard Strasser¹, Ovidiu Andronesi⁴, Stephan Gruber¹, Siegfried Trattnig^1,2, and Wolfgang Bogner^1,2

¹Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Division of Neurosciences, Comenius University in Bratislava, Martin, Slovakia, ⁴Harvard Medical School, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

In GABA-edited spectroscopy signal of macromolecules overlaps the signal of GABA. This macromolecular contribution to GABA signal (GABA+) is variable throughout the brain and can bias the quantification. We aimed to map the signal of macromolecules at 2.99 ppm using metabolite-nulled 3D MEGA-LASER MRSI. We found the GABA+/total creatine to be higher in white matter (45%), which contradicts the literature. The MM_2.99ppm was found higher in white matter as well (24%). The macromolecular tissue distribution is among other factors affecting the GABA+ signal, therefore the detection of GABA is preferable to GABA+ if the removal of macromolecules is possible.

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