Meeting Banner
Abstract #1058

Detection of MM using metabolite-nulled MEGA-LASER at 3T – A possible effect on GABA+ signal

Michal Považan1,2, Petra Hnilicová3, Gilbert Hangel1, Bernhard Strasser1, Ovidiu Andronesi4, Stephan Gruber1, Siegfried Trattnig1,2, and Wolfgang Bogner1,2

1Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Division of Neurosciences, Comenius University in Bratislava, Martin, Slovakia, 4Harvard Medical School, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

In GABA-edited spectroscopy signal of macromolecules overlaps the signal of GABA. This macromolecular contribution to GABA signal (GABA+) is variable throughout the brain and can bias the quantification. We aimed to map the signal of macromolecules at 2.99 ppm using metabolite-nulled 3D MEGA-LASER MRSI. We found the GABA+/total creatine to be higher in white matter (45%), which contradicts the literature. The MM2.99ppm was found higher in white matter as well (24%). The macromolecular tissue distribution is among other factors affecting the GABA+ signal, therefore the detection of GABA is preferable to GABA+ if the removal of macromolecules is possible.

This abstract and the presentation materials are available to members only; a login is required.

Join Here