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Abstract #1061

Metabolite cycled semi-LASER and STEAM at 9.4T. Comparison and in vivo results.

Ioannis-Angelos Giapitzakis1,2, Tingting Shao1, Nikolai Avdievitch1, Nicole Fichtner3,4, Ralf Mekle5, Roland Kreis 3, and Anke Henning1,6

1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate School of Neural and Behavioural Sciences, Tuebingen, Germany, 3Departments of Radiology and Clinical Research, University Bern, Bern, Switzerland, 4Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 5Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany, 6Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

The purpose of this study was the development of two new localization schemes for ultra high field (UHF) spectroscopic applications while utilizing the advantages of the Metabolite Cycling (MC) technique. In particular, a semi-adiabatic asymmetric pulse optimized for MC at 9.4T was incorporated into STEAM and semi-LASER localization schemes. In this study, these two new sequences along with the appropriate hardware setup were used to acquire in vivo 1H MRS data from the occipital lobe of the human brain and compare the corresponding results. In addition, the effect of frequency and phase correction based on the MC water spectra on data quality was investigated.

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