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Abstract #1060

Simultaneous Measurement of T1 and T2 Relaxation Times of Glutamate in the Frontal Cortex at 7T

Li An1, Shizhe Li1, and Jun Shen1

1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

Many central nervous system (CNS) abnormalities lead to significant changes in the microenvironment of glutamatergic neurons, which may alter relaxation times of glutamate. In this study, a method for simultaneously determining T1 and T2 of glutamate at 7T was presented. The method uses a point resolved spectroscopy (PRESS) sequence with multiple echo times, inversion-recovery times and RF suppression of aspartyl moiety of N-acetyl-aspartate (NAA).

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