Diurnal factors such as brain temperature, hydration and osmotic regulation have the potential to change metabolic profiles in two dimensional localised correlation spectroscopy (2D L-COSY). Ten Healthy subjects underwent repeated 2D L-COSY on a 3T system over a 10hour period at three time points (0700, 1200 and 1700) to evaluate diurnal effects on brain neurometabolites. Results show significant diurnal effects between morning and evening scans. The present findings highlight the importance of maintaining a specific time when spectral data is acquired, especially in longitudinal studies where the dynamic nature of subject can present a confounding factor.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords