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Abstract #1063

Diurnal variability of cerebral metabolites with 2D L-COSY

Jameen ARM1, Karen Ribbons2, Jeannette Lechner-Scott3, Kate Skehan3, Shiami Luchow3, and Saadallah Ramadan4

1University of Newcastle, Newcastle, Australia, 2Neurology, John Hunter Hospital, Australia, 3Hunter Medical Research Institute, Australia, 4University of Newcastle, Australia

Diurnal factors such as brain temperature, hydration and osmotic regulation have the potential to change metabolic profiles in two dimensional localised correlation spectroscopy (2D L-COSY). Ten Healthy subjects underwent repeated 2D L-COSY on a 3T system over a 10hour period at three time points (0700, 1200 and 1700) to evaluate diurnal effects on brain neurometabolites. Results show significant diurnal effects between morning and evening scans. The present findings highlight the importance of maintaining a specific time when spectral data is acquired, especially in longitudinal studies where the dynamic nature of subject can present a confounding factor.

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