Transcranial direct current stimulation (tDCS) modulates human behavior, neuronal patterns and metabolite concentrations. To unravel tDCS-induced alterations on the neuronal level we investigated tDCS-induced effects in older adults (50-79 years) using MRS to quantify GABA levels and resting-state fMRI to assess sensorimotor network strength and inter-hemispheric connectivity. Anodal, cathodal and sham tDCS were applied over the left sensorimotor region in a randomized, cross-over design. Compared to sham, anodal tDCS induced significantly reduced GABA levels, representing local plasticity, as well as lower large-scale network coupling and inter-hemispheric connectivity.
This abstract and the presentation materials are available to members only; a login is required.