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Abstract #1064

Transcranial direct current-induced modulation of GABA levels and resting-state functional connectivity in older subjects

Florian Schubert1, Daria Antonenko2, Florian Bohm2, Semiha Aydin1, Dayana Hayek2, Ulrike Grittner3, Agnes Flöel2,3, and Bernd Ittermann1

1Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 2Department of Neurology, NeuroCure Clinical Research Center, Charité, Berlin, Germany, 3Center for Stroke Research, Charité, Berlin, Germany

Transcranial direct current stimulation (tDCS) modulates human behavior, neuronal patterns and metabolite concentrations. To unravel tDCS-induced alterations on the neuronal level we investigated tDCS-induced effects in older adults (50-79 years) using MRS to quantify GABA levels and resting-state fMRI to assess sensorimotor network strength and inter-hemispheric connectivity. Anodal, cathodal and sham tDCS were applied over the left sensorimotor region in a randomized, cross-over design. Compared to sham, anodal tDCS induced significantly reduced GABA levels, representing local plasticity, as well as lower large-scale network coupling and inter-hemispheric connectivity.

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