Abstract #1065

The effect of high-intensity interval training on brain lactate levels during subsequent hypoglycemia in type 1 diabetes

Evita Wiegers¹, Hanne Rooijackers², Cees Tack², Arend Heerschap¹, Bastiaan de Galan², and Marinette van der Graaf^1,3

¹Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Internal Medicine, Radboud university medical center, Nijmegen, Netherlands, ³Pediatrics, Radboud university medical center, Nijmegen, Netherlands

Adaptations in brain lactate handling in response to hypoglycemia may play a role in the pathophysiology of impaired awareness of hypoglycemia (IAH). Therefore, we determined the effect of high-intensity interval training (HIIT)-induced hyperlactatemia on brain lactate during subsequent hypoglycemia in type 1 diabetic (T1DM) patients with IAH, in T1DM patients with normal awareness of hypoglycemia (NAH) and in healthy controls. Brain lactate concentration was determined using a J-difference editing semi-LASER ¹H-MRS sequence. After HIIT, brain lactate concentration increased most in T1DM IAH, consistent with an enhanced lactate transport capacity, and also dropped most during subsequent hypoglycemia, suggestive for increased lactate oxidation.

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