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Abstract #1069

Hyperpolarized 13C-pyruvate MRI of the liver and kidneys in rodent models of type 1 and type 2 diabetes

Cornelius von Morze1, Prasanna KR Allu2, Gene-Yuan Chang2, Irene Marco-Rius1, Eugene Milshteyn1, Catherine Gleason2, Daniel B Vigneron1, and David Pearce2

1Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Nephrology, UCSF, San Francisco, CA, United States

The purpose of this study was to characterize changes in hyperpolarized 13C-pyruvate spectra in the liver and kidneys of two contrasting models of diabetes, obese Zucker diabetic fatty (ZDF) rats and streptozotocin(STZ)-treated (insulin-deficient) wild type Zucker rats. The results were interpreted in combination with transcriptional analysis of freeze-clamped tissue samples from these animals. Hyperpolarized lactate levels were elevated in both models while hyperpolarized alanine signals clearly diverged, decreasing in the type 1 model but increasing in type 2. Overall, the results suggest a complex interplay of transcriptional and substrate-level effects in determining the metabolic phenotype in diabetes.

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