Abstract #1070

Multinuclear in vivo MR spectroscopy at 7T reveals differences in liver and muscle metabolism in NAFLD patients and healthy controls

Martin Gajdošík^1,2, Sabina Smajiš², Christian Kienbacher³, Lorenz Pfleger^1,2, Anton Luger², Siegfried Trattnig^1,4, Michael Trauner³, Michael Krebs², and Martin Krššák^1,2

¹High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁴Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Recent developments at 7T allowed for qualitative assessment of the hepatic lipids, faster measurement of glycogen and ATP turnover. Improved spectral resolution also enabled better separation and quantitation of hepatic metabolites. The aim of the study was to employ the advanced methods of multinuclear in vivo MR spectroscopy at 7T in the liver and muscles in non-alcoholic fatty liver disease (NAFLD) patients and healthy controls. Static and dynamic multinuclear MRS data, supported by mixed meal test and euglycemic-hyperinsulinemic clamp study, showed metabolic changes and disturbed interorgan crosstalk in NAFLD patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.