Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease leading to structurally irreversible bowel damage. The incidence of CD had been increasing in the past century epidemiologically . Accurate evaluation of CD activity is crucial for new therapeutic goals of mucosal healing, preventing bowel damage, limiting disability, and improving quality of life . Although colonoscopy remains the gold standard for assessing CD activity, it is invasive, limited to assessment of the small bowel, and not suitable for continuing monitoring of CD activity . Thus, seeking for alternative noninvasive and accurate approaches to assess CD activity is necessary.
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