Abstract #1075

Quantitative IVIM-DWI and DCE-MRI for assessment of bowel inflammation in Crohn’s disease

Stefanie Hectors¹, Sonja Gordic¹, Octavia Bane¹, Joana Torres², Judy Cho^2,3, Jean-Frederic Colombel², and Bachir Taouli¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The aims of this study were to quantify intravoxel incoherent motion DWI (IVIM-DWI) and DCE-MRI metrics and to assess the correlation between IVIM-DWI and DCE-MRI metrics in abnormal and normal appearing bowel segments in Crohn’s disease (CD) patients. ADC was significantly reduced in abnormal vs. normal bowel wall segments. A significant negative correlation between K^trans (measured with DCE-MRI) and perfusion fraction f (measured with IVIM-DWI) was observed. Our preliminary results suggest that IVIM-DWI could potentially be used for simultaneous assessment of perfusion and diffusion in the bowel wall of CD patients, which needs to be verified in a larger cohort of patients.

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