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Abstract #1078

Altered effective connectivity of dorsolateral prefrontal cortex in obsessive-compulsive disorder: a Granger causality analysis with resting-state fMRI

Hailong Li1, Xinyu Hu1, Ming Zhou1, Lu Lu1, Lianqing Zhang1, Xiaoxiao Hu1, Xuan Bu1, Xiaoqi Huang1, and Qiyong Gong1

1Huaxi Magnetic Resonance Research Centre(HMRRC),West China Hospital of Sichuan University, Chengdu, People's Republic of China

In current study, we demonstrated the altered effective connectivity between bilateral dorsolateral prefrontal cortex(DLPFC) and other brain regions in obsessive compulsive disorder(OCD) using the Granger causality analysis of resting-state functional MRI. We found that the effective connectivity from the bilateral DLPFC to some brain regions are increased or decreased in OCD ,and DLPFC is the important information flow center. We also observed positive correlations between the abnormal causal effect and clinical symptoms such as obsession. These findings provide insight into OCD-related neural network disorders and may potentially guide clinical diagnosis and treatment of OCD in the future.

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