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Abstract #1079

Reduced Functional Network Segregation is Associated with Reduced Structural Network Integration and Cost Pre-Operatively in Neonates with Complex Congenital Heart Disease (CHD)

Vincent Schmithorst1, Vince Lee1, Jodie K. Votava-Smith2, Richard Kim3, Rafael Ceschin4, Shahida Sulaiman1, Hollie Lai5, Jennifer Johnson6, Joan Sanchez De Toledo7, Stefan Bluml5, Lisa Paquette8, and Ashok Panigrahy1

1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2Division of Cardiology, Children's Hospital Los Angeles, 3Division of Pediatric Cardiothoracic Surgery, Children's Hospital Los Angeles, 4Department of Biomedical Informatics, University of Pittsburgh, 5Radiology, Children's Hospital Los Angeles, 6Division of Pediatric Cardiology, University of Pittsburgh School of Medicine, 7Department of Critical Care, University of Pittsburgh School of Medicine, 8Division of Neonatology, Children's Hospital Los Angeles

Neonates with complex congenital heart disease (CHD) pre-operatively show alterations in both structural network topology (as assessed via DTI) and functional network topology (as assessed via rs-fcMRI). Structurally, decreases in global efficiency, transitivity, and nodal efficiency are driven by decreased network cost and reflect alterations in white matter microstructure such as reduced fiber density. Functionally, CHD neonates display decreased network segregation in the later-developing frontal and temporal lobes, independent of cost, which likely reflect alterations at a more hierarchical level of architecture. These results may stem from different etiologies of brain dysmaturation (hypoperfusion vs. genetic factors).

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