At ultra-short time scales, intracellular metabolites are expected to experience less restriction, so that their apparent diffusion coefficient (ADC) as measured by diffusion-weighted MRS should approach the free intracellular diffusivity in a manner which depends on small microstructural features. In this work we use a unique gradient insert capable of reaching 1.5 T/m to measure metabolite ADC in the rat brain up to 665 Hz using oscillating gradients (corresponding to 0.21-ms diffusion time in the Mitra limit), in order to approach and estimate free intracellular diffusion.
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