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Abstract #1083

Accurate estimation of intra-axonal diffusivity and anisotropy of NAA in humans at 7T

Henrik Lundell1, Carson Ingo2, Tim Bjørn Dyrby1,3, and Itamar Ronen4

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 2Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 4C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Denmark

Diffusion weighted spectroscopy offers a unique probe for tissue microstructure and recent studies demonstrate NAA diffusivity as an independent marker of axonal health. In this study we address the problem of macroscopic dispersion of fiber directions and suggest the use of high angular gradient resolution and powder averaging as an experimentally inexpensive and accurate way to solve this problem. We explore the limits of this approach in simulations and in experiments on humans at 7T.

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