Abstract #1089

Diffusion anisotropy in breast cancer tissue corresponds to spatial patterns of collagen alignment from structure tensor analysis of histology

Colleen Bailey¹, Francesco Grussu², Bernard Siow^3,4, Thomy Mertzanidou¹, John H Hipwell¹, Julie Owen⁵, Patrycja Gazinska⁵, Sarah E Pinder⁵, Daniel C Alexander¹, David J Hawkes¹, and Eleftheria Panagiotaki¹

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²Institute of Neurology, University College London, London, United Kingdom, ³Centre for Advianced Biomedical Imaging, University College London, London, United Kingdom, ⁴Imaging, Francis Crick Insitute, London, United Kingdom, ⁵Breast Research Pathology, King's College London and Guy's Hospital, London, United Kingdom

Directional and anisotropy measures from a diffusion model composed of VERDICT compartments were compared with directional and anisotropy measures from structure tensor analysis of registered histology images. A significant positive correlation was found between the direction of the Zeppelin component of the diffusion model (assumed to represent the extracellular space) and the predominant direction of the structure tensor from the stroma, where the primary feature is aligned collagen. The correlation of anisotropy measures was weak, which may be due to difficulties in detecting alignment in regions with densely-packed collagen, which have nearly uniform intensity on H&E staining.

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