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Abstract #1094

Three-Dimensional Multiplexed Sensitivity Encoding and Reconstruction (3D-MUSER): 3D Phase Correction for 3D Multi-shot DWI

Hing-Chiu Chang1, Edward S. Hui1,2, Xiaoxi Liu1, Pui-Wai Chiu1, and Nan-kuei Chen3,4

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, 3Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 4Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States

3D interleaved DW-EPI with 2D multiplexed sensitivity encoding has been shown useful in achieving submillimeter DTI. Similar to other 3D DTI techniques, 2D phase variation is only considered in eliminating aliasing artifacts, thereby limiting feasible slab thickness. 3D phase correction is a potential strategy to significantly improve the image quality and feasible slab thickness of 3D DTI. To enable 3D phase correction, we develop a new reconstruction algorithm, and implement an EVI-based navigator echo for direct 3D phase measurement. Quantitative results show that the proposed algorithm can effectively eliminate aliasing artifacts and signal corruptions due to 3D inter-shot phase variations.

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