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Abstract #1095

Visualizing Axonal Damage in Multiple Sclerosis Using Double Diffusion Encoding MRI in a Clinical Setting

Grant Kaijuin Yang1,2, Qiyuan Tian1,2, Christoph Leuze2, Max Wintermark2, and Jennifer McNab2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

Double diffusion encoding (DDE) measurements of microscopic anisotropy show promise as a method of assessing neurodegeneration. Unfortunately, DDE has yet to be demonstrated in a clinical setting due to constraints in SNR and scan time. Here, we used an optimized gradient orientation scheme to show the first DDE measurements of microscopic anisotropy in multiple sclerosis (MS) patients. Five MS patients were scanned using a DDE sequence optimized to run in five minutes. The microscopic anisotropy maps show improved visualization of axonal damage compared to fractional anisotropy (FA) and may provide additional insight into changes in tissue microstructure.

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