Abstract #1119

Multiparametric MRI with spatiotemporal evaluation reveals potential therapy response biomarkers for 177Lu-octreotate therapy of mice with human neuroendocrine tumor

Mikael Montelius¹, Johan Spetz¹, Oscar Gustafsson¹, Evelin Berger², Ola Nilsson³, Maria Ljungberg¹, and Eva Forssell-Aronsson¹

¹Department of Radiation Physics, University of Gothenburg, Gothenburg, Sweden, ²Proteomics Core Facility, University of Gothenburg, Gothenburg, Sweden, ³Department of Pathology, University of Gothenburg, Gothenburg, Sweden

Tissue parameters derived from multiparametric MRI were evaluated as potential imaging biomarkers for therapy response assessment in mice with human neuroendocrine tumor treated with ¹⁷⁷Lu-octreotate. Animals were imaged before and repeatedly after ¹⁷⁷Lu-octreotate treatment, using T2w, IVIM-DWI, DCE-MRI, T1- and T2*-mapping techniques. MR-parameters were evaluated regionally and longitudinally, and quantitative proteomics was used to evaluate underlying biological response in central and peripheral tumor separately. Several MR-parameters showed strong correlation with tumor response, as verified by MRI-based tumor volume measurements, but also with proteins associated with radiobiological effects on tumor tissue. Spatial and temporal evaluation increased sensitivity of the methods.

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