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Abstract #1119

Multiparametric MRI with spatiotemporal evaluation reveals potential therapy response biomarkers for 177Lu-octreotate therapy of mice with human neuroendocrine tumor

Mikael Montelius1, Johan Spetz1, Oscar Gustafsson1, Evelin Berger2, Ola Nilsson3, Maria Ljungberg1, and Eva Forssell-Aronsson1

1Department of Radiation Physics, University of Gothenburg, Gothenburg, Sweden, 2Proteomics Core Facility, University of Gothenburg, Gothenburg, Sweden, 3Department of Pathology, University of Gothenburg, Gothenburg, Sweden

Tissue parameters derived from multiparametric MRI were evaluated as potential imaging biomarkers for therapy response assessment in mice with human neuroendocrine tumor treated with 177Lu-octreotate. Animals were imaged before and repeatedly after 177Lu-octreotate treatment, using T2w, IVIM-DWI, DCE-MRI, T1- and T2*-mapping techniques. MR-parameters were evaluated regionally and longitudinally, and quantitative proteomics was used to evaluate underlying biological response in central and peripheral tumor separately. Several MR-parameters showed strong correlation with tumor response, as verified by MRI-based tumor volume measurements, but also with proteins associated with radiobiological effects on tumor tissue. Spatial and temporal evaluation increased sensitivity of the methods.

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