For many years, research on recurrent glioblastoma has largely focused on therapy-induced cancer-cell changes. Herein, we show that gliomas resulting from naïve, non-irradiated DBT tumor cells implanted into irradiated mouse brains grow more rapidly than tumors resulting from naïve DBT cells implanted into non-irradiated mouse brains. Likewise, survival post-implantation is reduced, and MRI and histology document striking differences between naïve tumors implanted in irradiated vs. non-irradiated brain. Collectively, these data provide new insights into the enhanced invasiveness of recurrent gliomas and, importantly, demonstrate a novel recurrent glioblastoma model for further investigation of the long-term effects of radiotherapy on tumor microenvironment.
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