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Abstract #1133

Towards single-shot 3D MR elastography: Application to intrinsically activated motion fields in the human brain.

Sebastian Hirsch1, Rüdiger Stirnberg2, Tony Stöcker2,3, Florian Dittmann4, Jing Guo4, Eric Barnhill1, Jürgen Braun1, and Ingolf Sack4

1Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 3Department of Physics and Astronomy, University of Bonn, Germany, 4Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

This study introduces a single-shot 3D EPI sequence for rapid motion field acquisition. The method can be applied for MRE under pulsatile motion or for directly analyzing intrinsic motion fields in pulsatile organs such as the brain. Through 3D k-space sampling, inter-slice phase offset artifacts, which essentially result from 2D k-space MRE, are most effectively avoided. In a first application we used the new method for the measurement of intrinsic brain pulsation in the human brain and analyzed the intensity of deflection field components by stochastic sampling at rest and during Valsalva maneuver.

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