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Abstract #1143

Two compartmental diffusion model of skeletal muscle: application to aging and chronic limb suspension induced DTI changes in the medial gastrocnemius

Usha Sinha1, Vadim Malis2, and Shantanu Sinha3

1Physics, San Diego State University, San Diego, CA, United States, 2Physics, UC San Diego, San Diego, CA, United States, 3Radiology, UC San Diego, San Diego, CA, United States

Diffusion tensor imaging (DTI) is a powerful technique that allows one to probe tissue at the microstructural level. Though microarchitecture determines the DTI indices, a diffusion model is required to make inferences about the microstructure. We applied a two compartmental diffusion model for muscle to explain differences in the DTI indices with age and with atrophy induced by limb suspension. The model qualitatively explains the changes in DTI seen in limb suspension that is linked to decrease in muscle fiber diameter and in intracellular volume fraction. Extensions to the model are required to explain the age related changes in DTI.

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