Meeting Banner
Abstract #1144

In Vivo Follow-up of Low-Grade Femoral Cartilage Defects using Sodium MRI at 7T

Stefan Zbyn1,2,3, Vladimir Mlynarik1, Vladimir Juras1, Markus Schreiner1,4, Pavol Szomolanyi1, Didier Laurent5, Celeste Scotti5, Harry Haber5, Joerg Goldhahn5, Ewa Kubiak5, Oliver Bieri6, Stefan Marlovits7, Miika T. Nieminen2,8,9, and Siegfried Trattnig1,3

1High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 5Novartis Institutes for Biomedical Research, Basel, Switzerland, 6Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 7Department of Traumatology, Medical University of Vienna, Vienna, Austria, 8Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 9Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland

Sodium (23Na) MRI was employed for the evaluation of patients with ICRS Grade I-II cartilage defects at 7T. 23Na data from defect, weight-bearing, and non-weight-bearing region of femoral cartilage were obtained at baseline, 8-days, 3-months and 6-months follow-up. Significantly lower 23Na values were found in defect than in weight-bearing and non-weight-bearing regions at all time-points. While 23Na values in weight-bearing and in non-weight-bearing regions were stable over time, a significant decrease was found in the defects. 23Na-MRI allows noninvasive follow-up of changes in the cartilage GAG content and thus might be particularly useful for the evaluation of cartilage regenerating therapies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here