Abstract #1145

Cluster Analysis of Cartilage T2 and T1rho Relaxation Times: Can the Contralateral Knee be used as a Control in the ACL-injured population?

Uchechukwuka Monu^1,2, Emily McWalter³, Caroline Jordan⁴, Brian Hargreaves^1,2,5, and Garry Gold^2,5

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Mechanical Engineering, University of Saskatchewan, SK, Canada, ⁴Radiology and Biomedical Imaging, University of California San Francisco, CA, United States, ⁵Bioengineering, Stanford University, Stanford, CA, United States

In an ACL-injured population, longitudinal studies that use advanced MRI techniques such as T2 and T1rho mapping to assess cartilage health, typically compare ACL-injured knees with a separate healthy group or the contralateral knees. It is still unclear whether the contralateral knees can be used as a control group. Using a cluster analysis-based technique, we identify in the contralateral knees, significant increase in T1rho relaxation times over 1-year that is comparable to the increase in the ACL-injured knees. These focal cluster areas may represent degenerative changes and demonstrate that the contralateral knees may not be good controls.

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